ROS-mediated receptor kinase signalling in plants

March 2024

  • Date: Mar 20, 2024
  • Time: 02:00 PM - 03:30 PM (Local Time Germany)
  • Speaker: Elwira Smakowska-Luzan
  • Wageningen University & Research - Laboratory of Biochemistry, the Netherlands
  • Location: Central Building
  • Room: Seminar Room
  • Host: Marco Incarbone


Throughout their lifespan, plants must precisely sense and rapidly respond to environmental stresses to ensure proper growth and development. To sense and respond appropriately to this broad range of overlapping external stimuli, plants developed multiple strategies where the signalling molecules are perceived by sensing receptor kinases (RKs) to initiate orchestrated downstream signalling. One of the universal plant responses to different environmental challenges is the generation of Reactive Oxygen Species (ROS), and a family of Cysteine-Rich Receptor-Like Kinase (CRKs) is a long-speculated candidate for ROS sensors in the apoplast. The perception mechanism could rely on the direct oxidative modifications of the cysteine residues richly present in the extracellular domain (ECD) of this family of CRK receptors.

Consequent structural rearrangements of CRK ECDs rewire their inter- and intra-family interaction networks, resulting in consolidated cellular and physiological outputs. I will discuss our current views on the modes of activation and action of CRKs from the structural, biochemical, and physiological perspectives.


1. Hajný J, Prát T, Rydza N, Rodriguez L, Tan S, Verstraeten I, Domjan D, Mazur E, Smakowska-Luzan E, Smet W, Mor E, Nolf J, Yang B, Grunewald W, Molnár G, Belkhadir Y, De Rybel B, Friml J. Receptor kinase module targets PIN-dependent auxin transport during canalization. Science, 2020 Oct 30;370(6516):550-557

3. Mott GA*, Smakowska-Luzan E*, Pasha A, Parys K, Howton TC, Neuhold J, Lehner A, Grunwald K, Stolt-Bergner P, Provart NJ, Mukhtar MS, Desveaux D, Guttman DS, Belkhadir Y (2019). Map of physical interactions between extracellular domains of Arabidopsis leucine-rich repeat receptor kinases. Scientific Data, volume 6, article number: 190025

4. Smakowska-Luzan E, Mott GA, Parys K, Stegmann M, Howton TC, Layeghifard M, Neuhold J, Lehner A, Kong J, Grünwald K, Weinberger N, Satbhai SB, Mayer D, Busch W, Madalinski M, Stolt-Bergner P, Provart NJ, Mukhtar MS, Zipfel C, Desveaux D, Guttman DS, Belkhadir Y. An extracellular network of Arabidopsis leucine-rich repeat receptor kinases. Nature, 2018 Jan 18;553(7688):342-346.

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