Dr. Meng-Hsuan Lin (Gloria)

RESEARCH EXPERIENCE 

Postdoctoral Researcher (Feb. 2025 - Present)

Max Planck Institute of Molecular Plant Physiology.

Department 1 (Prof. Gutjahr): Root Biology and Symbiosis

Group Receptor Structures at the Plant-Microbe Interface (Group leader Dr. Förderer)

Postdoctoral Researcher (Feb. 2022 – Dec. 2024)

Molecular parasitology and HDX-MS. Prof. Dominique Soldati-Favre’s lab, Dept. of Microbiology

and Molecular Medicine, University of Geneva, Geneva, Switzerland

Visiting Researcher (Nov2023, Feb-Mar 2024)

Imperial College London. Collaborating with cryo-EM team at Prof. Steve J. Matthews's lab. 

Postdoctoral Researcher (Feb. 2021 – Jan. 2022)

X-ray crystallography and NMR. Prof. Chun-Hua Hsu’s lab, Dept. of Agricultural chemistry,

National Taiwan university, Taipei, Taiwan

EDUCATION

2021 PhD Genome and systems biology degree program, Academia sinica and National

Taiwan university, Taipei, Taiwan (Sep. 2014 - Jan. 2021)

Thesis: Structural and functional elucidations of intracellular pathogens derived-effector

proteins: macro domains from coronaviruses; host cellular apoptosis regulated protein PDCD5

and Cyclophilin 18 from Toxoplasma gondii. Date of defense: 15. Dec. 2020

2014 MS Department of Parasitology, College of Medicine, National Taiwan university, Taipei,

Taiwan (Sep. 2012 - Jun. 2014)

Thesis: Identification and characterization of a Maf-like transcription factor in Giardia lamblia.

2012 BS School of Medical laboratory science and biotechnology, Taipei medical university,

Taipei, Taiwan (Sep. 2008 - Jun. 2012)

MEDICAL RELATED TRAININGS

Jul 2012 License certified exam of medical technologist, qualified, Taiwan

Jan-Feb 2012 Morning part-time at clinical specimen collection of Tri-Service General Hospital

Aug-Dec 2011 Intern of medical technologist at Tri-Service General Hospital, Taiwan

Jul 2010 Exchange student to Juntendo University School of Medicine, Japan

2009 Laboratory intern of parasitology at Taipei medical university, Taiwan

RESEARCH SOCIETY SERVICES

May 2024 Chairperson of session “Cell biology1” in International Congress on Toxoplasmosis

Public health survey Jul 2011 Summer student medical volunteer program in Swaziland

HONORS AND AWARDS

Thesis Award, Biochemistry group, Chemistry National Meeting, Taiwan, 2021

SCHOLARSHIPS & FUNDS

2021 Higher education SPROUT project Postdoc Salary award (equals to 1810 EUR*13)

Donor: Ministry of Education, Taiwan

LANGUAGES

English: Fluent. Traditional Mandarin: Mother language. Japanese: Basic. French, German: Beginner.

PUBLICATIONS

1. (*) Gloria Meng-Hsuan Lin, Tsun-Ai Yu, Chi-Fon Chang, Chun-Hua Hsu. Proline isomerization and molten globular property of TgPDCD5 secreted from Toxoplasma gondii confers its regulation of heparin sulfate binding. JACS Au. 2024 Mar 20;4(5):1763-1774.Significant result: NMR spectrum of TgPDCD5 describes its flexibility related to its molten globular specialty. This study provided an in vitro angle to reveal the polysaccharide interaction toward a flexible molten globule with intrinsic disorder feature.
2. Amit Kumar, Oscar Vadas, Nicolas Dos Santos Pacheco, Xu Zhang, Kin Chao, Nicolas Darvill, Helena Ø Rasmussen, Yingqi Xu, Gloria Meng-Hsuan Lin, Fisentzos A Stylianou, Jan Skov Pedersen, Sarah L. Rouse, Marc L. Morgan, Dominique Soldati-Favre, Steve J. Matthews. Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii. Elife. 2023 Apr 4:12:e86049. Significant result: The crystal structure of the huge (~290kDa) protein glideosome-associated connector (TgGAC) presented a closed ring conformation. TgGAC processed plasma membrane interaction with its C-terminal PH domain as well as actin filament association with its N-terminus. This work suggested GAC contemporaneous multiple conformations.
3. Murali Mohana Rao Singuru, Yu-Chieh Liao, Gloria Meng-Hsuan Lin, Wei-Tzu Chen, Yu-Hsuan Lin, Ching Tat To, Wei-Ching Liao, Chun-Hua Hsu, Min-Chieh Chuang. Engineered multivalent DNA capsules for multiplexed detection of genotoxicants via versatile controlled release mechanisms. Biosensors and Bioelectronics. 2022 Nov 15, volume 216 114608.
4. (*) Meng-Hsuan Lin, Chao-Cheng Cho, Yi-Chih Chiu, Chia-Yu Chien, Yi-Ping Huang, Chi-Fon Chang, and Chun-Hua Hsu. Elucidating the tunability of binding behavior for the MERS-CoV macro domain with NAD metabolites. Communications Biology. 2021 Jan 27;4(1):123. Significant result: This study investigated that how temperature influence NAD metabolites binding abilities of MERS-CoV macro domain. Remarkably, protein could interact with NAD under human physiological temperature, but lost this interaction under room temperature.
5. (*) Meng-Hsuan Lin, Yi-Ping Huang, Chi-Fon Chang, Chun-Hua Hsu. NMR assignments of the macro domain from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Biomolecular NMR Assignments. 2021 Jan; 15(1):137-142.
6. (*) Meng-Hsuan Lin, San-Chi Chang, Yi-Chih Chiu, Bo-Chen Jiang, Tsung-Han Wu, Chun-Hua Hsu. Structural, Biophysical, and Biochemical Elucidation of the SARS-CoV-2 Nonstructural Protein 3 Macro Domain. ACS Infectious Diseases. 2020 Nov 13;6(11):2970-2978. Significant result: The crystal structure of SARS-CoV-2 macro domain reported here was solved within the first year of COVID pandemic. Coupling with the structural information, this study deciphered the inhibition on mono-ADP-ribosylation and the interaction with poly-ADP-ribose of this protein.
7. (*) Meng-Hsuan Lin, Po-Chih Kuo, Yi-Chih Chiu, Yu-Yung Chang, Seng-Chia Chen, Chun-Hua Hsu. The crystal structure of protein-transporting chaperone BCP1 from Saccharomyces cerevisiae. Journal of Structural Biology. 2020 Oct 1;212(1):107605.
8. (*) Meng-Hsuan Lin, Tsun-Ai Yu, Chi-Fon Chang, Yoshifumi Nishikawa, Chun-Hua Hsu. NMR resonance assignments of the programmed cell death protein 5 (PDCD5) from Toxoplasma gondii. Biomolecular NMR Assignments. 2020 Oct; 14(2):277-280.
9. Chin-Hung Sun, Shih-Che Weng, Jui-Hsuan Wu, Szu-Yu Tung, Li-Hsin Su, Meng-Hsuan Lin, Gilbert Aaron Lee. DNA topoisomerase IIIβ promotes cyst generation by inducing cyst wall protein gene expression in Giardia lamblia. Open Biology. 2020 Feb; 10(2):190228. Significant result: This work investigated the DNA binding ability, DNA superstructure relaxation ability, the relationship between cyst wall regulating transcriptional factors and DNA topoisomerase IIIβ from Giardia lamblia.
10. Chao-Cheng Cho, Chia-Yu Chien, Yi-Chih Chiu, Meng-Hsuan Lin, Chun-Hua Hsu. Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans. Nature Communications. 2019 Apr 2;10(1):1491.
11. Tesmine Martin, Yuan-Chao Lou, Chun-Chi Chou, Shu-Yi Wei, Sushant Sadotra, Chao-Cheng Cho, Meng-Hsuan Lin, Jung-Hsuang Tai, Chun-Hua Hsu, Chinpan Chen. Structural basis of interaction between dimeric cyclophilin 1 and Myb1 transcription factor in Trichomonas vaginalis. Scientific Reports. 2018 Apr 3;8(1):5410.
12. Chao-Cheng Cho, Meng-Hsaun Lin, Chine-Ying Chuang, Chun-Hua Hsu. Macro Domain from Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Is an Efficient ADP-ribose Binding Module: CRYSTAL STRUCTURE AND BIOCHEMICAL STUDIES. Journal of Biological Chemistry. 2016 Mar 4;291(10):4894-902.