Publikationen von A. Bar-Even

Jinich, A., Flamholz, A., Ren, H., Kim, S.-J., Sanchez-Lengeling, B., Cotton, C. A. R., Noor, E., Aspuru-Guzik, A. & Bar-Even, A. Quantum chemistry reveals thermodynamic principles of redox biochemistry. PLoS Computational Biology 14, (2018).

Kruesemann, J. L., Lindner, S. N., Dempfle, M., Widmer, J., Arrivault, S., Debacker, M., He, H., Kubis, A., Chayot, R., Anissimova, M., Marliere, P., Cotton, C. A. R. & Bar-Even, A. Artificial pathway emergence in central metabolism from three recursive phosphoketolase reactions. The FEBS Journal 285, 4367–4377 (2018).

Lindner, S. N., Ramirez, L. C., Kruesemann, J. L., Yishai, O., Belkhelfa, S., He, H., Bouzon, M., Doring, V. & Bar-Even, A. NADPH-Auxotrophic E-coil: A Sensor Strain for Testing in Vivo Regeneration of NADPH. ACS Synthetic Biology 7, 2742–2749 (2018).

Trudeau, D. L., Edlich-Muth, C., Zarzycki, J., Scheffen, M., Goldsmith, M., Khersonsky, O., Avizemer, Z., Fleishman, S. J., Cotton, C. A. R., Erb, T. J., Tawfik, D. S. & Bar-Even, A. Design and in vitro realization of carbon-conserving photorespiration. Proceedings of the National Academy of Sciences of the United States of America 115, E11455–E11464 (2018).

Yishai, O., Bouzon, M., Doering, V. & Bar-Even, A. In Vivo Assimilation of One-Carbon via a Synthetic Reductive Glycine Pathway in Escherichia coli. ACS Synthetic Biology 7, 2023–2028 (2018).

Aslan, S., Noor, E. & Bar-Even, A. Holistic bioengineering: Rewiring central metabolism for enhanced bioproduction. Biochemical Journal 474, 3935–3950 (2017).

Erb, T. J., Jones, P. R. & Bar-Even, A. Synthetic metabolism: metabolic engineering meets enzyme design. Current Opinion in Chemical Biology 37, 56–62 (2017).

Yishai, O., Goldbach, L., Tenenboim, H., Lindner, S. N. & Bar-Even, A. Engineered Assimilation of Exogenous and Endogenous Formate in Escherichia coli. ACS Synthetic Biology 6, 1722–1731 (2017).

Bar-Even, A. Formate Assimilation: The Metabolic Architecture of Natural and Synthetic Pathways. Biochemistry 55, 3851–3863 (2016).

Zelcbuch, L., Lindner, S. N., Zegman, Y., Slutskin, I. V., Antonovsky, N., Gleizer, S., Milo, R. & Bar-Even, A. Pyruvate Formate-Lyase Enables Efficient Growth of Escherichia coli on Acetate and Formate. Biochemistry 55, 2423–2426 (2016).

Davidia, D., Noorb, E., Liebermeisterc, W., Bar-Even, A., Flamholze, A., Tummlerf, K., Barenholza, U., Goldenfelda, M., Shlomig, T. & Miloa, R. Global characterization of in vivo enzyme catalytic rates and their correspondence to in vitro k cat measurements. Proceedings of the National Academy of Sciences of the United States of America 113, 3401–3406 (2016).

Noor, E., Flamholz, A., Bar-Even, A., Davidi, D., Milo, R. & Liebermeister, W. The Protein Cost of Metabolic Fluxes: Prediction from Enzymatic Rate Laws and Cost Minimization. PLoS Computational Biology 12, (2016).

Yishai, O., Lindner, S. N., Gonzalez de la Cruz, J., Tenenboim, H. & Bar-Even, A. The formate bio-economy. Current Opinion in Chemical Biology 35, 1–9 (2016).

Poust, S., Piety, J., Bar-Even, A., Louw, C., Baker, D., Keasling, J. D. & Siegel, J. B. Mechanistic Analysis of an Engineered Enzyme that Catalyzes the Formose Reaction. Chembiochem 16, 1950–1954 (2015).

Siegel, J. B., Smith, A. L., Poust, S., Wargacki, A. J., Bar-Even, A., Louw, C., Shen, B. W., Eiben, C. B., Tran, H. M., Noor, E., Gallaher, J. L., Bale, J., Yoshikuni, Y., Gelb, M. H., Keasling, J. D., Stoddard, B. L., Lidstrom, M. E. & Baker, D. Computational protein design enables a novel one-carbon assimilation pathway. Proceedings of the National Academy of Sciences of the United States of America 112, 3704–3709 (2015).

Bar-Even, A., Milo, R., Noor, E. & Tawfik, D. S. The Moderately Efficient Enzyme: Futile Encounters and Enzyme Floppiness. Biochemistry 54, 4969–4977 (2015).

Zelcbuch, L., Razo-Mejia, M., Herz, E., Yahav, S., Antonovsky, N., Kroytoro, H., Milo, R. & Bar-Even, A. An In Vivo Metabolic Approach for Deciphering the Product Specificity of Glycerate Kinase Proves that Both E. coli's Glycerate Kinases Generate 2-Phosphoglycerate. PLoS One 10, (2015).

Noor, E., Bar-Even, A., Flamholz, A., Reznik, E., Liebermeister, W. & Milo, R. Pathway Thermodynamics Highlights Kinetic Obstacles in Central Metabolism. PLoS Computational Biology 10, (2014).

Jinich, A., Rappoport, D., Dunn, I., Sanchez-Lengeling, B., Olivares-Amaya, R., Noor, E., Bar-Even, A. & Aspuru-Guzik, A. Quantum Chemical Approach to Estimating the Thermodynamics of Metabolic Reactions. Scientific Reports 4, (2014).

Zelcbuch, L., Antonovsky, N., Bar-Even, A., Levin-Karp, A., Barenholz, U., Dayagi, M., Liebermeister, W., Flamholz, A., Noor, E., Amram, S., Brandis, A., Bareia, T., Yofe, I., Jubran, H. & Milo, R. Spanning high-dimensional expression space using ribosome-binding site combinatorics. Nucleic Acids Research 41, (2013).