Cell type-specific regulation of brassinosteroid signaling

Oktober 2022

  • Datum: 05.10.2022
  • Uhrzeit: 14:00 - 15:30
  • Vortragende(r): Jenny Russinova
  • Center for Plant Systems Biology, VIB, Ghent University, Belgium
  • Ort: MPI-MP
  • Raum: U.019
  • Gastgeber: Duarte Dionísio Figueiredo & John Lunn

Our previous research revealed that brassinosteroid (BR) signal transduction pathway shares signaling components with the signaling pathway controlling stomatal development. Stomatal cell lineage is an archetypal example of asymmetric cell division (ACD), which is necessary for plant survival. In stomatal lineage of Arabidopsis thaliana, the GSK3-like kinase BR INSENSITIVE2 (BIN2) phosphorylates and renders inactive both, the plasma membrane localized mitogen-activated protein kinase signaling module and the nuclear transcription factor SPEECHLESS to promote and restrict ACD, respectively. These mutually exclusive activities depend on the stomatal lineage-specific scaffolding protein POLAR. POLAR recruits BIN2 into a distinct macromolecular complex in the plasma membrane to initiate ACD. BR hormones negatively regulated BIN2 activity, but how they govern stomatal development remains unclear. By mapping the single-cell transcriptome of stomatal lineages with either exogenous BRs or the specific BIN2 inhibitor, we revealed the mechanistic framework underlying the involvement of BRs in the induction of stomatal ACD.

Lu Q, Houbaert A, Ma Q, Huang J, Lieven Sterck L, Zhang C, Benjamins R, Coppens F, Breusegemn FV, Russinova E (2022) Adenosine monophosphate deaminase modulates BIN2 activity through hydrogen peroxide-induced oligomerization. Plant Cell doi: 10.1093/plcell/koac203

Zhang C, Lauster T, Tang W, Houbaert A, Zhu S, Eeckhout D, De Smet I, De Jaeger G, Jacobs TB, Xu T, Müller S, Russinova E (2022) ROPGAP-dependent interaction between brassinosteroid and ROP2-GTPase signaling controls pavement cell shape in Arabidopsis. Current Biology S0960-9822(21)01730-9.

Vukašinović N, Wang Y, Vanhoutte I, Fendrych M, Guo B, Kvasnica M, Jiroutová P, Oklestkova J, Strnad M, Russinova E (2021) Local brassinosteroid biosynthesis enables optimal root growth. Nature Plants 7(5):619-632. doi: 10.1038/s41477-021-00917-x

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