Anne Krapp - Early nitrate signalling by NLP transcription factors in Arabidopsis

Nitrate, beside its role as essential nutrient, acts as a signal molecule for triggering many responses to changes in N availability. Several molecular players involved in the regulation by nitrate have been identified recently, but the nitrate signaling pathway from nitrate perception to the regulation of gene expression has not been completely described so far. Among the transcription factors governing the early nitrate response, NIN-like protein 7 (NLP7) plays a key role in early nitrate signaling, orchestrating the expression of dozens of key genes involved in nitrate signaling and metabolism. I will summarizes the current understanding of the NLP-dependent nitrate signaling pathway and beyond.

Five representative publications (corresponding author **):

• Krapp A** (2015) Plant nitrogen assimilation and its regulation: a complex puzzle with missing pieces. Curr Opin Plant Biol 25, 115-122
• Marchive C, Roudier F, Castaings L, Bréhaut V, Blondet E, Colot V, Meyer C, Krapp A** (2013). Nuclear retention of the transcription factor NLP7 orchestrates the early response to nitrate in plants. Nature Comms 4, 1714
• Kiba T, Feria-Bourrellier AB , Lafouge F, Lezhneva L, Boutet S, Orsel M, Brehaut V, Miller A, Daniel-Vedele F, Sakakibara H, Krapp A **(2011). The Arabidopsis Nitrate Transporter NRT2.4 Plays a Double Role in Roots and Shoots of Nitrogen-starved Plants. Plant Cell 24: 245-258.
• Krapp A**, Berthomé R, Orsel M, Mercey-Boutet, S, Yu A, Castaings L, Elfthieh S, Major H, Renou JP, Daniel-Vedele F (2011) Arabidopsis roots and shoots show distinct temporal adaptation pattern towards N starvation. Plant Physiol 157, 1255-8
• Castaings L, Carmago A, Pocholle D, Gaudon V, Texier Y, Boutet-Mercey S, Taconnat L, Renou JP, Daniel-Vedele F, Fernandez E, Meyer C, Krapp A** (2009) The nodule inception-l ike protein 7 modulates nitrate sensing and metabolism in Arabidopsis . Plant Journal 57, 426-35.