Mizuki Takenaka - The role of MORF proteins in the RNA editing complexes in plant organelles
August 2017
- Datum: 08.08.2017
- Uhrzeit: 14:00 - 15:30
- Vortragende(r): Mizuki Takenaka
- Ort: Central Building
- Raum: Seminar Room
- Gastgeber: Ralph Bock
RNA editing in flowering plants alters 400-500 and 30-40 cytidines to
uridine in mitochondria and plastids, respectively. PLS class pentatricopeptide
repeat (PPR) proteins have been assigned to be involved in single or few RNA
editing sites in plant organelles. Recently proposed “PPR code” in which
nucleotide identity of each PPR module is determined by the amino acid
combinations at two key positions basically explains the sequence specificity of
each editing factor, though it requires further improvement. In contrast to the
PPR proteins, the multiple organellar RNA editing factors (MORF) proteins
influence editing at many sites, for several of which individual PPR proteins
are also required. Selective interactions between MORF proteins and PPR
proteins are necessary for the editing function, implying formation of complex
RNA editosomes in plant organelles. I discuss the possible function of MORF
proteins in the RNA editosomes with 3D structural data.