TRR356 Seminar: Relieving the burden of replication: selective autophagy protects host cells against virus-induced organelle remodeling
November 2023
- Datum: 14.11.2023
- Uhrzeit: 13:00 - 14:30
- Vortragende(r): Marion Clavel
- MPI of Molecular Plant Physiology, Potsdam
- Ort: MPI-MP
- Raum: U.019
- Gastgeber: Caroline Gutjahr
Abstract:
RNA viruses are intracellular pathogen who
depend on extensive manipulation of subcellular organelles to support their
replication, significantly altering their morphology. Little is known about the
cellular stress response involved in coping with such stress in both plants and
animals. Selective autophagy is a well-established cellular quality control
mechanism that is deployed to face a multitude of environmental and
developmental challenges. Versatility and selectivity towards cargoes is
achieved by a multitude of selective autophagy receptor (SAR) proteins, that
bridge the interaction between cargo and ATG8. Using an AP-MS screen in
ss(+)RNA viruses-Arabidopsis interactions, we identify two metabolic enzyme
families that bind to ATG8 in an AIM-dependent manner and undergo
virus-dependent autophagic degradation. We propose that these enzymes moonlight
as SARs, as they transition to a monomeric state upon virus infection and
enable autophagic degradation of pro-cell death factors. Thus, we uncover a
critical function of selective autophagy in promoting survival in cells
undergoing active viral replication and unproductive immune response.