Disulfide reduction systems in Arabidopsis: metabolic and developmental functions

Post-translational redox modifications can affect the function of numerous proteins by modulating their activity, their subcellular localization, their stability, or their interactions with partner proteins. Most of these modifications are influenced or controlled by the disulfide reductases thioredoxin (TRX) or glutaredoxin (GRX). The first part of the talk will present evidence for redox regulation of some cytosolic metabolic enymes by TRX or GRX in Arabidopsis. The second part of the talk will present evidence for the crucial role of a multidomain iron-sulfur cluster glutaredoxin GRXS17 in meristem activities and in the response to heat stress.