Das Max-Planck-Institut für Molekulare Pflanzenphysiologie hat regelmäßig herausragende Forscher zu Gast, die Vorträge über ihre aktuellen Projekte halten und so den Austausch unter den Wissenschaftlern fördern.

Eine Übersicht über die kommenden Veranstaltungen finden Sie hier. Seminare finden für gewöhnlich Mittwochs in der Zeit von 14:00 Uhr bis 15:30 Uhr im Seminarraum im Zentralgebäude (1.052 und 1.053) statt, Abweichungen in Zeit und Ort sind jedoch möglich.

December 2015

Circadian control of seasonal rhythms in Arabidopsis

Plants respond to seasonal cues in order to anticipate the expected environmental changes that accompany the changing seasons. Well-known examples of seasonal control of development in plants are photoperiodic control of flowering and hypocotyl elongation, both of which are regulated by the circadian clock via the CONSTANS (CO) and PHYTOCHROME INTERACTING FACTOR (PIF) transcription factors, respectively. We recently developed an integrated mathematical model of these pathways, identifying novel signalling dynamics across hundreds of co-regulated transcripts. Beyond these canonical examples of seasonal regulation, we have also identified a general principle of photoperiodic regulation of protein expression. This regulation arises from changes in the timing of bulk protein synthesis with photoperiod. We validated a simple model of this effect using quantitative transcriptomic and proteomic datasets across a range of photoperiods. My ongoing work seeks to identify other aspects of plant physiology that show seasonal responses, and to uncover the molecular mechanisms of these responses. The ongoing proliferation of genome-scale datasets in plant biology means that computational approaches are fast becoming a vital tool for exploring new hypotheses in these diverse contexts. [mehr]

The Plant Cell in the new age of scientific publishing

The Plant Cell is a premier venue for publication of your best research in plant biology. With a new Editor-in-Chief on board, this year brings many changes to publication and the peer review process. As an online-only journal, there is a flat fee for publication, which includes post-review scientific editing and full color images for technical conformity and visually aesthetic presentation of your data. An expanded board of scientific editors who are encouraged to solicit reviews from a broader community of researchers offers the authors expert review and guidance. The pre-review process involving at least two editors enables expedited decisions so that full-review is restricted to the papers deemed most likely to be approved after peer-review. A post-review discussion between reviewers and multiple editors prior to rendering a decision to the author ensures fair and scholarly appreciation of the authors work. We will make suggestions on how to take advantage of the true peer-review process of The Plant Cell to ensure that your work is reviewed and appreciated by the most appropriate audience. We will also inform you of new initiatives at the journal and what we are doing to advertise your work to the broader community ( [mehr]

Origin and Function of the Autophagosome Membrane

We studied the biogenesis of the autophagosome membrane by examining an early covalent event in autophagy, the lipidation of a cytosolic protein, LC3-I to form LC3-II. Using membranes from a cultured cell line deficient in lipidation, we demonstrated that the ERGIC was a major site for lipidation of LC3. Starvation induces the activation of a PI3 kinase to produce PI3P, which is required for the formation of LC3-II. We find that starved cells transfer a pool of COPII proteins from the ER to the ERGIC from which novel COPII vesicles bud that may be the immediate precursor of the phagophore membrane. Inflammation induces the abundant secretion of IL-1 β from macrophages and neutrophils by a process that appears to be independent of the normal secretory pathway. Co-expression of IL-1β and caspase 1 reconstituted the stress-induced secretion of mature IL-1β in HEK293 cells under conditions where cell lysis was minimal. Cells deficient in the lipidation of a cytosolic protein, LC-3, required for autophagy, accumulate IL-1β in the cytoplasm. Using cell fractionation experiments we found that IL-1β precursor and mature forms co-isolated with phagophore membranes marked by their content of lipidated LC-3. Using cells depleted of ATG2, a protein required for phagophore closure to produce a double-membrane mature authophagosome, we found that mature IL-1β, but not the precursor or control proteins were resistant to proteinase k, suggesting that IL-1β enters the lumen of the phagophore membrane rather than being engulfed into the cyoplasmic interior of the organelle. We have identified a targeting signal and a role for hsp90 in a translocation event that localizes IL-1β to the interior of the phagophore envelope. Fusion of the autophagosome with the plasma membrane would then result in the release of soluble IL-1β to the extracellular space. [mehr]

Science Journalism at Laborjournal, Lab Times,... And Elsewhere

There is no standard route for becoming a science writer or science journalist. However, at least in terms of education the vast majority enters science journalism from the science side. This talk will give an overview of how Laborjournal and – later – Lab Times once entered the scene and what exactly have since proven to be the conceptual key elements for their establishment and success. One of these key elements clearly was that Laborjournal and Lab Times right from the start took a couple of different approaches than most other science print media. On the other hand, the constant comparison with other science media has proven very useful in order to identify important key ingredients of having success and fun (!) in the science journalism business in general. Some insights in this regard shall also be shared and discussed in this talk. [mehr]

January 2016

Andreas Weber


Torgny Näsholm


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