Complete publication list

Publications of Lothar Willmitzer

Journal Article (329)

  1. 1.
    Bozek, K.; Khrameeva, E. E.; Reznick, J.; Omerbašić, D.; Bennett, N. C.; Lewin, G. R.; Azpurua, J.; Gorbunova, V.; Seluanov, A.; Regnard, P. et al.; Wanert, F.; Marchal, J.; Pifferi, F.; Aujard, F.; Liu, Z.; Shi, P.; Pääbo, S.; Schröder, F.; Willmitzer, L.; Giavalisco, P.; Khaitovich, P.: Lipidome determinants of maximal lifespan in mammals. Scientific Reports (2017)
  2. 2.
    Bucher, R.; Veyel, D.; Willmitzer, L.; Krattinger, S.; Keller, B.; Biglera, L.: Combined GC- and UHPLC-HR-MS Based Metabolomics to Analyze Durable Anti-fungal Resistance Processes in Cereals. Chimia 71 (4), pp. 156 - 159 (2017)
  3. 3.
    Jin, M.; Zhang, X.; Zhao, M.; Deng, M.; Du, Y.; Zhou, Y.; Wang, S.; Tohge, T.; Fernie, A. R.; Willmitzer, L. et al.; Brotman, Y.; Yan, J.; Weiwei, W.: Integrated genomics-based mapping reveals the genetics underlying maize flavonoid biosynthesis. BMC Plant Biology 17 (1), 17 (2017)
  4. 4.
    Li, Q.; Bozek, K.; Xu, C.; Guo, Y.; Sun, J.; Pääbo, S.; Sherwood, C. C.; Hof, P. R.; Ely, J. J.; Li, Y. et al.; Willmitzer, L.; Giavalisco, P.; Khaitovich, P.: Changes in lipidome composition during brain development in humans, chimpanzees, and macaque monkeys. Molecular Biology and Evolution 34 (5), pp. 1155 - 1166 (2017)
  5. 5.
    Veyel, D.; Kierszniowska, S.; Kosmacz, M.; Sokolowska, E.; Michaelis, A.; Luzarowski, M.; Szlachetko, J.; Willmitzer, L.; Skirycz, A.: System-wide detection of protein-small molecule complexes suggests extensive metabolite regulation in plants. Scientific Reports (2017)
  6. 6.
    de Abreu e Lima, F.; Westhues, M.; Cuadros-Inostroza, Á.; Willmitzer, L.; Melchinger, A. E.; Nikoloski, Z.: Metabolic robustness in young roots underpins a predictive model of maize hybrid performance in the field. The Plant Journal 90 (2), pp. 319 - 329 (2017)
  7. 7.
    de Abreu e Lima, F.; Westhues, M.; Cuadros-Inostroza, A.; Willmitzer, L.; Melchinger, A. E.; Nikoloski, Z.: Metabolic robustness in young roots underpins a predictive model of maize hybrid performance in the field. The Plant Journal 90 (2), pp. 319 - 329 (2017)
  8. 8.
    Cuadros-Inostroza, A. C.; Ruiz-Lara, S.; Gonzalez, E.; Eckardt, A.; Willmitzer, L.; Pena-Cortes, H.: GC-MS metabolic profiling of Cabernet Sauvignon and Merlot cultivars during grapevine berry development and network analysis reveals a stage- and cultivar-dependent connectivity of primary metabolites. Metabolomics 12 (2), 39 (2016)
  9. 9.
    Machado, M.; Bromke, M. A.; Domingues Júnior, A.P.; Marçal Vieira Vaz, M.G.; Rosa, R.M.; Vinson, C.C.; Sabir, J.S.; Rocha, D.I.; Martins, M.A.; Araújo, W.L. et al.; Willmitzer, L.; Szymanski, J.; Nunes-Nesi, A.: Comprehensive metabolic reprograming in freshwater Nitzschia palea strains undergoing nitrogen starvation is likely associated with its ecological origin. Algal Research 18, pp. 116 - 126 (2016)
  10. 10.
    Riewe, D.; Jeon, H.-J.; Lisec, J.; Heuermann, M. C.; Schmeichel, J.; Seyfarth, M.; Meyer, R. C.; Willmitzer, L.; Altmann, T.: A naturally occurring promoter polymorphism of the Arabidopsis FUM2 gene causes expression variation, and is associated with metabolic and growth traits. The Plant Journal 88, pp. 826 - 838 (2016)
  11. 11.
    Rudovich, N. N.; Pivovarova, O.; Mazuch, J.; Wendt, S.; Tuvia, N.; Kruse, M.; Nikiforova, V.; Murahovschi, V.; Erban, A.; Mosig, A. et al.; Sticht, C.; Goegebakan, O.; Willmitzer, L.; Kramer, A.; Pfeiffer, A. F.: Insulin directly regulates clock gene expression in the insulin-dependent tissues in vivo and in vitro. Diabetologia 59, p. S324 - S324 (2016)
  12. 12.
    Scossa, F.; Brotman, Y.; de Abreu e Lima, F.; Willmitzer, L.; Nikoloski, Z.; Tohge, T.; Fernie, A. R.: Genomics-based strategies for the use of natural variation in the improvement of crop metabolism. Plant Science 242, pp. 47 - 64 (2016)
  13. 13.
    Skirycz, A.; Kierszniowska, S.; Meret, M.; Willmitzer, L.; Tzotzos, G.: Medicinal Bioprospecting of the Amazon Rainforest: A Modern Eldorado ? Trends in Biotechnology 34 (10), pp. 781 - 790 (2016)
  14. 14.
    Tenenboim, H.; Burgos, A.; Willmitzer, L.; Brotman, Y.: Using lipidomics for expanding the knowledge on lipid metabolism in plants. Biochimie 130, pp. 91 - 96 (2016)
  15. 15.
    Weiwei, W.; Brotman, Y.; Willmitzer, L.; Yan, J.; Fernie, A. R.: Broadening Our Portfolio in the Genetic Improvement of Maize Chemical Composition. Trends in Genetics 32 (8), pp. 459 - 469 (2016)
  16. 16.
    Wu, S.; Alseekh, S.; Cuadros-Inostroza, A. C.; Fusari, C. M.; Mutwil, M.; Kooke, R.; Keurentjes, J. B.; Fernie, A. R.; Willmitzer, L.; Brotman, Y.: Combined Use of Genome-Wide Association Data and Correlation Networks Unravels Key Regulators of Primary Metabolism in Arabidopsis thaliana. PLoS Genetics 12 (10), e1006363 (2016)
  17. 17.
    Bozek, K.; Wei, Y.; Yan, Z.; Liu, X.; Xiong, J.; Sugimoto, M.; Tomita, M.; Paeaebo, S.; Sherwood, C. C.; Hof, P. R. et al.; Ely, J. J.; Li, Y.; Steinhauser, D.; Willmitzer, L.; Giavalisco, P.; Khaitovich, P.: Organization and Evolution of Brain Lipidome Revealed by Large-Scale Analysis of Human, Chimpanzee, Macaque, and Mouse Tissues. Neuron 85 (4), pp. 695 - 702 (2015)
  18. 18.
    Bromke, M. A.; Hochmuth, A.; Tohge, T.; Fernie, A. R.; Giavalisco, P.; Burgos, A.; Willmitzer, L.; Brotman, Y.: Liquid chromatography high-resolution mass spectrometry for fatty acid profiling. The Plant Journal 81 (3), pp. 529 - 536 (2015)
  19. 19.
    Bromke, M. A.; Sabir, J. S.; Alfassi, F. A.; Hajarah, N. H.; Kabli, S. A.; Al-Malki, A. L.; Ashworth, M. P.; Meret, M.; Jansen, R. K.; Willmitzer, L.: Metabolomic Profiling of 13 Diatom Cultures and Their Adaptation to Nitrate-Limited Growth Conditions. PLoS One 10 (10), e0138965 (2015)
  20. 20.
    Pant, B. D.; Burgos, A.; Pant, P.; Cuadros-Inostroza, A. C.; Willmitzer, L.; Scheible, W.-R.: The transcription factor PHR1 regulates lipid remodeling and triacylglycerol accumulation in Arabidopsis thaliana during phosphorus starvation. Journal of Experimental Botany 66 (7), pp. 1907 - 1918 (2015)
  21. 21.
    Sade, D.; Shriki, O.; Cuadros-Inostroza, A. C.; Tohge, T.; Semel, Y.; Haviv, Y.; Willmitzer, L.; Fernie, A. R.; Czosnek, H.; Brotman, Y.: Comparative metabolomics and transcriptomics of plant response to Tomato yellow leaf curl virus infection in resistant and susceptible tomato cultivars. Metabolomics 11 (1), pp. 81 - 97 (2015)
  22. 22.
    Bozek, K.; Wei, Y.; Yan, Z.; Liu, X.; Xiong, J.; Sugimoto, M.; Tomita, M.; Paeaebo, S.; Pieszek, R.; Sherwood, C. C. et al.; Hof, P. R.; Ely, J. J.; Steinhauser, D.; Willmitzer, L.; Bangsbo, J.; Hansson, O.; Call, J.; Giavalisco, P.; Khaitovich, P.: Exceptional Evolutionary Divergence of Human Muscle and Brain Metabolomes Parallels Human Cognitive and Physical Uniqueness. PLoS Biology 12 (5), e1001871 (2014)
  23. 23.
    Feher, K.; Lisec, J.; Römisch-Margl, L.; Selbig, J.; Gierl, A.; Piepho, H.-P.; Nikoloski, Z.; Willmitzer, L.: Deducing Hybrid Performance from Parental Metabolic Profiles of Young Primary Roots of Maize by Using a Multivariate Diallel Approach. PLoS ONE (2014)
  24. 24.
    Meret, M.; Kopetzki, D.; Degenkolbe, T.; Kleessen, S.; Nikoloski, Z.; Tellstroem, V.; Barsch, A.; Kopka, J.; Antonietti, M.; Willmitzer, L.: From systems biology to systems chemistry: metabolomic procedures enable insight into complex chemical reaction networks in water. RSC Advances 4 (32), pp. 16777 - 16781 (2014)
  25. 25.
    Mettler, T.; Mühlhaus, T.; Hemme, D.; Schöttler, M. A.; Rupprecht, J.; Idoine, A.; Veyel, D.; Pal, S. K.; Yaneva-Roder, L.; Winck, F. V. et al.; Sommer, F.; Vosloh, D.; Seiwert, B.; Erban, A.; Burgos, A.; Arvidsson, S.; Schönfelder, S.; Arnold, A.; Günther, M.; Krause, U.; Lohse, M.; Kopka, J.; Nikoloski, Z.; Mueller-Roeber, B.; Willmitzer, L.; Bock, R.; Schroda, M.; Stitt, M.: Systems Analysis of the Response of Photosynthesis, Metabolism, and Growth to an Increase in Irradiance in the Photosynthetic Model Organism Chlamydomonas reinhardtii. The Plant Cell 26 (6), pp. 2310 - 2350 (2014)
  26. 26.
    Ramadan, A.; Sabir, J. S. M.; Alakilli, S. Y. M.; Shokry, A. M.; Gadalla, N. O.; Edris, S.; Al-Kordy, M. A.; Al-Zahrani, H. S.; El-Domyati, F. M.; Bahieldin, A. et al.; Baker, N. R.; Willmitzer, L.; Irgang, S.: Metabolomic Response of Calotropis procera Growing in the Desert to Changes in Water Availability. PLoS One 9 (2), e87895 (2014)
  27. 27.
    Sade, D.; Sade, N.; Shriki, O.; Lerner, S.; Gebremedhin, A.; Karavani, A.; Brotman, Y.; Osorio, S.; Fernie, A. R.; Willmitzer, L. et al.; Czosnek, H.; Moshelion, M.: Water Balance, Hormone Homeostasis, and Sugar Signaling Are All Involved in Tomato Resistance to Tomato Yellow Leaf Curl Virus. Plant Physiology 165 (4), pp. 1684 - 1697 (2014)
  28. 28.
    Schroeder, F.; Lisso, J.; Obata, T.; Erban, A.; Maximova, E.; Giavalisco, P.; Kopka, J.; Fernie, A. R.; Willmitzer, L.; Muessig, C.: Consequences of induced brassinosteroid deficiency in Arabidopsis leaves. BMC Plant Biology 14, 309 (2014)
  29. 29.
    Schulz, P.; Jansseune, K.; Degenkolbe, T.; Meret, M.; Claeys, H.; Skirycz, A.; Teige, M.; Willmitzer, L.; Hannah, M. A.: Poly(ADP-Ribose)Polymerase Activity Controls Plant Growth by Promoting Leaf Cell Number. PLoS One (2014)
  30. 30.
    Szymanski, J.; Brotman, Y.; Willmitzer, L.; Cuadros-Inostroza, A. C.: Linking Gene Expression and Membrane Lipid Composition of Arabidopsis. The Plant Cell 26 (3), pp. 915 - 928 (2014)
  31. 31.
    Tenenboim, H.; Smirnova, J.; Willmitzer, L.; Steup, M.; Brotman, Y.: VMP1-deficient Chlamydomonas exhibits severely aberrant cell morphology and disrupted cytokinesies. BMC Plant Biology 14, 121 (2014)
  32. 32.
    Antonio, C.; Mustafa, N. R.; Osorio, S.; Tohge, T.; Giavalisco, P.; Willmitzer, L.; Rischer, H.; Oksman-Caldentey, K. M.; Verpoorte, R.; Fernie, A. R.: Analysis of the interface between primary and secondary metabolism in Catharanthus roseus cell cultures using 13C-stable isotope feeding and coupled mass spectrometry. Molecular Plant 6 (2), pp. 581 - 584 (2013)
  33. 33.
    Bromke, M. A.; Giavalisco, P.; Willmitzer, L.; Hesse, H.: Metabolic Analysis of Adaptation to Short-Term Changes in Culture Conditions of the Marine Diatom Thalassiosira pseudonana. PLoS One (2013)
  34. 34.
    Caldana, C.; Li, Y.; Leisse, A.; Zhang, Y.; Bartholomaeus, L.; Fernie, A. R.; Willmitzer, L.; Giavalisco, P.: Systemic Analysis of Inducible Target of Rapamycin Mutants Reveal a General Metabolic Switch Controlling Growth in Arabidopsis thaliana. The Plant Journal 73 (6), pp. 897 - 909 (2013)
  35. 35.
    Doerr, J. R.; Yu, Y.; Milanovic, M.; Beuster, G.; Zasada, C.; Daebritz, J. H. M.; Lisec, J.; Lenze, D.; Gerhardt, A.; Schleicher, K. et al.; Kratzat, S.; Purfuerst, B.; Walenta, S.; Mueller-Klieser, W.; Graeler, M.; Hummel, M.; Keller, U.; Buck, A. K.; Doerken, B.; Willmitzer, L.; Reimann, M.; Kempa, S.; Lee, S.; Schmitt, C. A.: Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. Nature 501 (7467), pp. 421 - 425 (2013)
  36. 36.
    Howlett, B. J.; Brotman, Y.; Landau, U.; Cuadros-Inostroza, A.; Tohge, T.; Fernie, A. R.; Chet, I.; Viterbo, A.; Willmitzer, L.: Trichoderma-Plant Root Colonization: Escaping Early Plant Defense Responses and Activation of the Antioxidant Machinery for Saline Stress Tolerance. PLoS Pathogens 9 (3), e1003221 (2013)
  37. 37.
    Melzer, N.; Wittenburg, D.; Hartwig, S.; Jakubowski, S.; Kesting, U.; Willmitzer, L.; Lisec, J.; Reinsch, N.; Repsilber, D.: Investigating associations between milk metabolite profiles and milk traits of Holstein cows. Journal of dairy science 96 (3), pp. 1521 - 1534 (2013)
  38. 38.
    Perez-Perez, J. M.; Esteve-Bruna, D.; Gonzalez-Bayon, R.; Kangasjarvi, S.; Caldana, C.; Hannah, M. A.; Willmitzer, L.; Ponce, M. R.; Micol, J. L.: Functional redundancy and divergence within the Arabidopsis RETICULATA-RELATED gene family. Plant Physiology 162 (2), pp. 589 - 603 (2013)
  39. 39.
    Riedelsheimer, C.; Brotman, Y.; Meret, M.; Melchinger, A. E.; Willmitzer, L.: The maize leaf lipidome shows multilevel genetic control and high predictive value for agronomic traits. Scientific Reports (2013)
  40. 40.
    Sade, D.; Brotman, Y.; Eybishtz, A.; Cuadros-Inostroza, A.; Fernie, A. R.; Willmitzer, L.; Czosnek, H.: Involvement of the hexose transporter gene LeHT1 and of sugars in resistance of tomato to Tomato yellow leaf curl virus. Molecular Plant 6 (5), pp. 1707 - 1710 (2013)
  41. 41.
    Toepfer, N.; Caldana, C.; Grimbs, S.; Willmitzer, L.; Fernie, A. R.; Nikoloski, Z.: Integration of Genome-Scale Modeling and Transcript Profiling Reveals Metabolic Pathways Underlying Light and Temperature Acclimation in Arabidopsis. The Plant Cell 25 (4), pp. 1197 - 1211 (2013)
  42. 42.
    Wittenburg, D.; Melzer, N.; Willmitzer, L.; Lisec, J.; Kesting, U.; Reinsch, N.; Repsilber, D.: Milk metabolites and their genetic variability. Journal of Dairy Science 96 (4), pp. 2557 - 2569 (2013)
  43. 43.
    Bocobza, S.; Willmitzer, L.; Raikhel, N. V.; Aharoni, A.: Discovery of New Modules in Metabolic Biology Using ChemoMetabolomics. Plant Physiology 160 (3), pp. 1160 - 1163 (2012)
  44. 44.
    Brotman, Y.; Lisec, J.; Meret, M.; Chet, I.; Willmitzer, L.; Viterbo, A.: Transcript and metabolite analysis of the Trichoderma-induced systemic resistance response to Pseudomonas syringae in Arabidopsis thaliana. Microbiology 158 (Pt 1), pp. 139 - 146 (2012)
  45. 45.
    Brotman, Y.; Landau, U.; Pnini, S.; Lisec, J.; Balazadeh, S.; Mueller-Roeber, B.; Zilberstein, A.; Willmitzer, L.; Chet, I.; Viterbo, A.: The LysM Receptor-Like Kinase LysM RLK1 Is Required to Activate Defense and Abiotic-Stress Responses Induced by Overexpression of Fungal Chitinases in Arabidopsis Plants. Molecular Plant 5 (5), pp. 1113 - 1124 (2012)
  46. 46.
    Caldana, C.; Fernie, A. R.; Willmitzer, L.; Steinhauser, D.: Unraveling retrograde signaling pathways: finding candidate signaling molecules via metabolomics and systems biology driven approaches. Frontiers in Plant Science 3, p. 267 (2012)
  47. 47.
    Degenkolbe, T.; Giavalisco, P.; Zuther, E.; Seiwert, B.; Hincha, D. K.; Willmitzer, L.: Differential remodeling of the lipidome during cold acclimation in natural accessions of Arabidopsis thaliana. The Plant Journal 72, pp. 972 - 982 (2012)
  48. 48.
    Gupta, K. J.; Shah, J. K.; Brotman, Y.; Jahnke, K.; Willmitzer, L.; Kaiser, W. M.; Bauwe, H.; Igamberdiev, A. U.: Inhibition of aconitase by nitric oxide leads to induction of the alternative oxidase and to a shift of metabolism towards biosynthesis of amino acids. Journal of Experimental Botany 63 (4), pp. 1773 - 1784 (2012)
  49. 49.
    Hische, M.; Larhlimi, A.; Schwarz, F.; Fischer-Rosinsky, A.; Bobbert, T.; Assmann, A.; Catchpole, G. S.; Pfeiffer, A. F.; Willmitzer, L.; Selbig, J. et al.; Spranger, J.: A distinct metabolic signature predicts development of fasting plasma glucose. Journal of Clinical Bioinformatics 2 (1), p. 3 (2012)
  50. 50.
    Hubberten, H.-M.; Klie, S.; Caldana, C.; Degenkolbe, T.; Willmitzer, L.; Hoefgen, R.: An additional role of O-acetylserine as a sulphur status independent regulator during plant growth. Plant Journal 70 (4), pp. 666 - 677 (2012)
loading content