Mechanisms of centrioles assembly

Abstract

Understanding the organizing principles driving assembly of cellular organelles is an important pursuit in biology. The centriole is a microtubule-based organelle essential for the formation of flagella, cilia and centrosomes. The centriole exhibits a striking 9-fold radially symmetrical arrangement of microtubules organized around a likewise symmetrical cartwheel. I will discuss published and ongoing work aimed at deciphering the mechanisms governing centriole assembly across systems.

References

doi: 10.1038/s41580-025-00921-5
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doi: 10.1038/s41467-021-26329-1