Phasing viruses in RNA regulation
Februar 2025
- Datum: 19.02.2025
- Uhrzeit: 14:00 - 15:00
- Vortragende(r): Anders Hafrén
- The Swedish University of Agricultural Sciences, Uppsala, Sweden
- Ort: Zentralgebäude
- Raum: Seminar Raum
- Gastgeber: Marco Incarbone
Abstract
Post-transcriptional regulation involves many distinct processes that influence RNA stability and translation. Some of these processes appear to be influenced by biomolecular condensations characterized as membrane-less organelles that assemble through liquidliquid
phase separation in an RNA-binding-protein- and RNA-dependent manner. While our insights into the specific function of these highly diverse condensates are continuously increasing, they have remained quite enigmatic especially regarding functions of the condensation process itself. One of my groups research interests is regulation mediated by such condensation processes within viral infections. Generally, many disease-causing plant viruses produce very high levels of viral RNA and rely on extensive protein production, with exposure to the RNA regulative machineries potential as friend and foe. In the main part of my presentation, I will narrow the focus to our recent work on the Cauliflower mosaic virus (CaMV) model virus, its viroplasm condensation and touch on functional implications of this process in infection.