I have an extensive background in metabolic engineering of prokaryotic organisms. I completed my diploma thesis on polyphosphate metabolism in the institute of biotechnology at the research center Jülich. During my PhD studies, at the institute of molecular microbiology and biotechnology at Münster University, I investigated and engineered the central metabolism of C. glutamicum. I then joined the institute of Genetics of Prokaryotes at Bielefeld University, where I continued my metabolic engineering work, with a special emphasis on alternative carbon sources, sugar transport, glycolysis, and the pentose phosphate pathway. I further engineered C. glutamicum for the production of various compounds of interest. Later, I joined Algenol Biofuels in Berlin, working in strain development of Cyanobacteria. At Arren’s group I design and implement synthetic pathways for formate assimilation in E. coli, using state of the art metabolic engineering and genome editing techniques.
I gained my diploma in biochemistry at the University of Potsdam. During my studies I became interested in microbiology, and therefore I made my Diploma thesis in intestine microbiology, studying the effect of microorganisms on the formation and excretion of potential carcinogenic nutrients. After my Diploma, I worked for a while in a medicine products company. I completed my PhD studies in the field of geological microbiology, working at the Institute of Earth and Environmental Science at the University of Potsdam. There, I developed and constructed high-pressure, high temperature incubation systems for cultivation of extremophiles as well as for the extraction of organic compounds from condensed organic matter. At AG Bar-Even, I am responsible for maintaining and operating the technical equipment.
I received my B.Sc. degree in biology at the University of Gaziantep (Turkey), studying molecular identification of pathogens of chick-pea. I completed my master's degree at Linköping University (Sweden), where I investigated the adaptation of landrace barley to day-length and frost-conditions, making use of 19th century barley collected at different locations in Europe. I have recently obtained my PhD in Molecular Biology from the Swedish Agricultural University in Uppsala. During my PhD studies, I demonstrated a novel strategy of utilizing intermediates of the de novo fatty acid biosynthesis pathway in vegetative tissue for the production of wax esters in tobacco plants. I further introduced a new metabolic pathway to reallocate carbon flux in the endosperm of rice plant. In Dr. Bar-Even's group, I engineer synthetic photorespiration pathways, using the model bacterium E. coli as a testbed, with the aim to implement the novel routes in photosynthetic organisms.
I studied for my undergraduate degree at the University of Cambridge (Part II Biochemistry), writing a short thesis on the roles of alkanes in cyanobacteria. I continued my education at Imperial College London where I studied for a Masters of Research in Structural Biology, investigating both structural mechanisms of control in the Calvin cycle and modelling residence times of water in intrinsically disordered proteins. My PhD research was also at Imperial College, where I investigated replacing the Calvin cycle in a photosynthetic bacterium, Synechocystis sp. PCC 6803, with an alternative carbon fixation cycle. In Dr. Bar-Even’s group I work to expand possible formate assimilation pathways by investigating pathways reliant on the promiscuous activities of relevant enzymes.
Being passionate about both the environment and the amazing capabilities of microbes, I studied Environmental Sciences and Biotechnology at Wageningen University, The Netherlands. I pursued my PhD as well in Wageningen at the Laboratory of Microbiology. For my PhD studies I focussed on the genetic engineering of rhodopsin photosystems and improved production of various other membrane proteins in Escherichia coli. In Arren Bar-Even’s group I am investigating the reprogramming of CO2 fixation and formate assimilation pathways in the industrially relevant autotroph Cupriavidus necator.
I received my bachelor's degree in chemical engineering at the Pusan National University, South Korea. During my studies I got interested in bioprocess and made my Diploma thesis in metabolic engineering of prokaryotic organisms to produce hydrogen. I completed my master's degree at the same university where I further engineered E. coli to increase hydrogen production with a special emphasis on carbon flux analysis. Then, I joined Ramon Gonzalez's group at Rice University at Houston, USA for the PhD degree where I engineered orthogonal reversed beta oxidation pathways for carbon elongation to develop microbial cell factories which can be used for biofuel and biochemical production.
At Arren Bar-Even's Group, I focus on developing synthetic pathways in E. coli for the one-carbon assimilation.
Being a fan of self-sufficiency, I studied Agronomy and Biotechnology at the Hebrew University (Israel) towards my bachelor's degree, imagining myself working later in the field. During that time I found out I love molecular biology and metabolism, and dedicated most of my time as a student worker learning new techniques. I did my master’s degree at the Weizmann Institute of Science (Israel) aiming, together with Arren, at metabolically engineering the bacterium E. coli to assimilate formic acid.
I now continue this project at Max Planck Institute. My work revolves around the design, construction, and testing of novel metabolic routes in E. coli.
I earned my bachelor’s degree in Pharmaceutical Engineering from the National Polytechnic Institute in Mexico. I did my master’s studies at the Center for Research and Advanced Studies, also within the National Polytechnic Institute. During my master I studied genetic interactions in yeast to elucidate the mechanisms that control the ageing process. At the Max Planck Institute I metabolically engineer yeast, aiming to establish formate assimilation within this model organism.
I studied Plant Protection at the Huazhong Agricultural University in Wuhan (China) and wrote my bachelors thesis about the isolation of bioactive compounds from Atractylodes lancea. I was fascinated by the field of synthetic biology and moved to explore triterpenoids biosynthesis pathway in the edible medicinal fungi Poria cocos for my master degree, also at the Huazhong Agricultural University.
In Dr. Bar-Even's group, I work on engineering E. coli to establish formaldehyde assimilation.
I studied Biochemistry at the University of Tübingen where I graduated with a thesis at the Friedrich Miescher Laboratory of the Max Planck Society on the control of robust ordering of cell cycle events. For my Master degree I moved to the University of Heidelberg and visited the University of Edinburgh. There, I worked on a variety of different projects from transcriptional regulation over optimization of photosynthesis to optogenetic tools. For my Master thesis at the Max Planck Institute for Medical Research I worked on a high-throughput protocol to test engineered light-sensitive dimers.
In Dr. Bar-Even’s Group I am investigating ways to improve photosynthesis by constructing synthetic carbon-neutral photorespiration bypass routes. Combining engineered and natural enzymes, I test novel pathways in E. coli to evaluate their functionality in vivo and perform directed evolution for further optimization.
For my undergraduate degree, I studied Molecular Biology at the University of Potsdam where I did my BSc thesis on epigenetic regulation of heat stress memory in A. thaliana. Following my interest in applied science, I moved to Strasbourg (France), where I studied Biotechnology at the École Supérieure de Biotechnologie. There, I received a double MSc degree in Synthetic Biology and Structural Biology after writing my thesis on the development of DNA Aptamers against post-transcriptionally modified proteins at the MPI for Immunology and Epigenetics in Freiburg.
In the group of Dr. Bar-Even, I focus on the establishment of modified versions of the Serine-Cycle that allow formate assimilation in E.coli.
I studied Pharmaceutical Biochemistry and received a Bachelor’s degree at The National Autonomous University of Mexico, where I investigated biodiesel and biomethane production. For my Master studies, I joined the program of Biomedicine and Molecular Biotechnolgy, in the National Polytechnic Institute of Mexico. I worked in the Agricultural Microbiology group, studying the hydrolytic activities (cellulases, pectinases and xylanases) of the actinomycete Micromonospora sp. L5 for the production of second generation biofuels. As part of this project I undertook a residential research placement at the department of Microbiology and Molecular Genetics of the University of Salamanca (Spain) and a second in the School of Materials at the University of Manchester (United Kingdom). In Dr. Bar-Even’s group, I work on harnessing formate dehydrogenases and their application in plants to increase growth through formate assimilation and production.
Besides the general understanding of science, my bachelor studies in Biotechnology at the Braunschweig University of Technology gave me insights into biological cultivation processes, molecular biology and biochemistry. I did my Bachelor Thesis in the department of genetics focusing on plant-pathogen interaction. Afterwards, I decided to do my master studies in Biochemistry and Molecular Biology at the University of Potsdam. During my thesis, I followed up with engineering a part of a formate assimilation pathway designed by Dr. Arren Bar-Even. That was when my passion for metabolic engineering started and made me want to get deeper into the field. So, I started my PhD at the Max-Planck Institute working in the Group of Dr. Bar-Even exploring formatotrophic and autotrophic growth of microorganisms.
I received my Bachelor’s degree in life sciences from Sri Venkateswara University, India and Master’s degree in biochemistry with a thesis on “Alkaline protease production from Bacillus. spp” from the same university. After my masters, I worked as a research fellow at JNCASR, India where I earned diverse scientific research experience as I had worked on microbial biocatalysts for the production of butanol and developed an inducible synthetic operon to engineer isobutanol production pathway. I also worked on cell biology aspects to develop assays to monitor flux of autophagy in terms of intracellular trafficking of pathogens and degradation of protein aggregates.
In Dr. Arren Bar-Even’s group, I am doing my PhD on engineering synthetic C1 assimilation pathways in yeast.
I started my career with my bachelor’s degree in biological science at the University of Constance with main focus on biochemistry. Currently, I am doing my Master of Science at the University of Potsdam and joined the AG Bar-Even in November 2017 to complete my thesis. For that, under the supervision of Dr. Steffen Lindner, I work on the implementation of synthetic pathways in E. coli using exogenous enzymes.
I studied biology at Freie Universität Berlin and went on to start my Master’s degree in biochemistry at ETH Zürich. Being excited about applied research on metabolism and synthetic biology, I decided to join the Bar-Even Group for my Master Thesis in spring 2018.
For my ongoing thesis, I work on 2 projects: Under the supervision of Dr. Selcuk Aslan, I investigate energy conservation in E.coli and aim to implement a pathway for conversion of an abundant waste-compound to value-added chemicals. In addition, I work together with Dr. Steffen Lindner to implement the first steps of a novel synthetic carbon fixation pathway.
I studied biotechnology at Universitat Autònoma de Barcelona. In that time, I found out how amazing microbes are and their capabilities to produce valuable compounds from waste. The industrial use of microorganisms for novel processes fascinated me and led me to start my Biosystems Engineering studies at Wageningen University. My thesis was centered on CO2 capture from air on carbon materials.
In Arren Bar-Even´s group, I am tuning the expression of CO2 fixation and formate assimilation pathways in the industrially relevant autotroph Cupriavidus necator.”
For my undergraduate degree, I followed a chemical engineering program at Maastricht University (NL), which I concluded with a thesis on the production of thermo-sensitive polymeric micelles for transarterial chemo-embolization. My interests shifted from chemistry towards biotechnology after realizing, that many problems of chemical synthesis can potentially be overcome with enzymatic reactions. For my master’s degree, I therefore studied molecular Biotechnology at Wageningen University (NL), writing my thesis on the immortalization of sponge cells to establish a continuous cell useable in biotechnological applications.
In the group of Arren Bar-Even, I am working on the modular introduction of formate assimilation pathways in Cupriavidus necator.
I received my degree in chemical engineering at the Technical University of Madrid, Spain. After working on different projects in research and consultancy, I decided to move on and explore a new field where I could combine my technical knowledge and passion for science. Therefore, I started a Master in Bioinformatics at Wageningen University, the Netherlands. There, I completed my master thesis at the systems and synthetic biology department working on metabolic modeling of C. glutamicum for the production of valuable plant aromatics.
In the group of Dr. Bar-Even, I work with genome scale metabolic models. Core models of different microorganisms are generated, capturing the central metabolism pathways in order to study the efficiency of assimilation of one carbon compounds.
Being intrigued about microbes and the posibility of engineering their genomes, I did my Biotechnology BSc at Universitat Politécnica de Valencia. After working on different microbiology projects, the possibility to make bacteria do more with less, engineer new routes and explore the potential of synthetic biology brought me to do my Biotechnology MSc and Molecular Life Sciences MSc at Wageningen University. For my Molecular Life Sciences MSc studies I focussed on the amplification of the signal to noise ratio of a detection system via the genetic engineering implementation of a quorum sensing mechanism on bacteria. While for my Biotechnology MSc studies I worked on the implementation of a CRISPR system in Neisseria meningitidis for the generation of an OMV vaccines platform.
In Arren Bar-Even’s group I am engineering the reductive glycine pathway for formate assimilation and CO2 fixation.
I studied Biotechnology Bsc at the Alma Mater Studiorum of Bologna. I did my Bachelor thesis at the department of biochemistry in the group of Bioenergetics. After graduating, I decided to apply for a master in Cellular and Molecular Biotechnology at the Wageningen University in the Netherlands. I did my Master thesis in the BacGen group of Wageningen, working on the development of a CRISPR/CAS9 toolbox and studying DNA repair systems in Rhodobacter sphaeroides.
Currently, I am doing my internship at the Bar-Even group, working with Nico Claassens on formate assimilation pathways in Ralstonia eutropha.
Currently I'm studying Biosciences at the University of Potsdam with focus on Molecularbiology and Physiology and I joined the AG Bar-Even to work on my bachelor thesis. Under the supervision of Sebastian, I'm researching enzymes for alternative energy production in E. coli.
I studied economics at McGill University and in 2016 moved to Germany to begin a B.Sc in Molecular Ecosystem Sciences at Göttingen University. I am interested in applying synthetic biology to support exoplanet colonization. In Arren Bar-Even’s group, I am doing an internship project to assess the environmental and economic impact of novel sustainable microbial food systems on global land and water use.