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Max-Planck-Institut für molekulare Pflanzenphysiologie

Dr Monika Chodasiewicz (Kosmacz)

Am Mühlenberg 1

14476 Potsdam

Brandenburg

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Dr Monika Chodasiewicz (Kosmacz)

Dr Monika Chodasiewicz (Kosmacz)

Dr Monika Chodasiewicz (Kosmacz)

Position:

Wissenschaftlicher Mitarbeiter

Forschungsinteressen

My work is focused on cAMP as small signaling molecule that acts as a secondary messenger in animal cells and it is known to be involved in regulation of many important biological processes including primary metabolism, cell cycle, response to stress and hormonal homeostasis. Despite the fact that cAMP-dependent signaling cascades are well understood in animals, little is known about its potential function in plants. Although the presence of cAMP was recently confirmed in plant cells its protein interactors, with the exception of the family of the CNGC ion channels, are still nonidentified.

  In order to identify potential cAMP – protein interactions in plants, we decided to apply a range of new approaches, initially developed for mode of action research in the pharmacology field. Specifically, we adapted Thermal Proteome Profiling (TPP) and affinity purification (AP) assays to plant lysates. Starting with native lysates prepared from Arabidopsis cell cultures and rosettas, using state of the art proteomic approach, we identified candidates for cAMP interactors. Recently we demonstrated, that 2',3'-cAMP is involved in stress granule formation due to its interaction with Rbp47b.

 With our studies we hope to unravel the mystery of cAMP signaling in plants.

Vita

 EDUCATION

1.09.2010 - 28.05.2014          PhD in Molecular Plant Physiology at Max Plank Institute

o Dissertation: Characterization of the oxygen sensing mechanism in plants. under supervision of Prof. Dr. Joost van Dongen

1.09.2005 - 31.08.2010         Diploma in Biotechnology at University of Szczecin, Poland.

o Master thesis: Studies on the dynamic of the karyokinetic spindle in pollen mother cells of Tritisecale crosses. under supervision of Prof. Stanisława Rogalska

WORK AND RESEARCH EXPERIENCE

1.06.2015 – now                    Postdoc position at Prof. Dr. Lothar Willmitzer group at the Max-Planck-Institute of Molecular Plant Physiology

29.05.2014 – 29.05.2015      Postdoc position at Dr. Fritz Kragler group at the Max-Planck-Institute of Molecular Plant Physiology

01.09.2010 – 28.05.2014      PhD at the Max-Planck-Institute for Molecular Plant Physiology

01. 09. 2009 – 28. 02. 2010  Internship at the Max-Planck-Institute of Molecular Plant Physiology, Potsdam-Golm, Germany

01. 08. 2009 – 31. 08. 2009    Internship at University of Szczecin, Department of cell Biology

01. 07. 2009 – 30. 07. 2010    Internship at Forensic Medicine

 PUBLICATION RECORD:

1. Kosmacz M., Luzarowski M., Kerber O., Leniak E., Gutiérrez-Beltrán E., Moreno JC., Gorka M., Szlachetko J., Veyel D., Graf A., Skirycz A., (2018) “Interaction of 2’,3’-cAMP with Rbp47b plays a role in stress granule formation” Plant Physiology – Accepted.

2. Luzarowski M., Kosmacz M., Sokolowska E., Jasinska W., Willmitzer L., Veyel D., Skirycz A. (2017) “Affinity purification with metabolomic and proteomic analysis unravels diverse roles of nucleoside diphosphate kinases’’ Journal of experimental botany doi:10.1093/jxb/erx183

3. Veyel D., Kierszniowska S., Kosmacz M., Sokolowska E.M., Michaelis A., Luzarowski M., Szlachetko J., Willmitzer L., Skirycz A. (2017) “System-wide detection of protein-small molecule complexes suggests extensive metabolite regulation in plants’’ Scientific Reports doi:10.1038/srep42387

4. Bui L.T, Giuntoli B., Kosmacz M., Parlanti S., Licausi F. (2015) “Constitutively expressed ERF-VII transcription factors redundantly activate the core anaerobic response in Arabidopsis thaliana’’ Plant Science doi: 10.1016/j.plantsci.2015.03.008

5. Kosmacz M., Parlanti S., Schwarzlander M., Kragler F., Licausi F., van Dongen J.T. (2014) “Oxygen Sensing in Plants - Concentration Dependent and Time-Resolved Characterization of RAP2.12 Stability and Localization” Plant Cell and Environment doi: 10.1111/pce.12493

6. Giuntoli B., Lee C.S., Licausi F., Kosmacz M., Oosumi T., van Dongen J.T., Bailey-Serres J., Perata P. (2014) “A trihelix DNA binding protein counterbalances hypoxia-responsive transcriptional activation in Arabidopsis” Plos Biology doi: 10.1371/journal.pbio.1001950

7. Weits D., Giuntoli B., Kosmacz M., Parlanti S., Hubberten H-M., Hoefgen R., Perata P., van Dongen J.T. and Licausi F. (2014) “Plant cysteine oxidases control the oxygen-dependent branch of the N-end rule pathway” Nature communications doi:10.1038/ncomms4425

8. Kosmacz M., and Weits D., 2014 “Oxygen perception in plants” van Dongen J.T., and Licausi F., (eds.) Low oxygen stress in plants. Springer, Heidelberg.

9. Licausi F., Kosmacz M., Weits D., Giuntoli B., Giorgi F.M., Voesenek L.A.C.J., Perata P., and van Dongen J.T. (2011) “Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization” Nature 479, 419-422

10. Paparelli E., Gonzali S., Parlanti S., Novi G., Giorgi F. M., Licausi F., Kosmacz M., Feil R. Lunn J.E., Brust H., van Dongen J.T., Steup M., and Perata P. (2012)      “Misexpression of a Chloroplast Aspartyl Protease Leads to Severe Growth Defects and Alters Carbohydrate Metabolism in Arabidopsis” Plant Physiology  160: 1237-1250

Organisationseinheit (Abteilung, Gruppe, Einrichtung):

  • Abteilung 1 (Willmitzer)
  • Gene und kleine Moleküle
  • PostDoc
 
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