Jenny Russinova - Trafficking of Plant Receptor Kinases: When the Intracellular Logistics Matters

  • Datum: 30.11.2016
  • Uhrzeit: 14:00 - 15:30
  • Vortragende(r): Jenny Russinova
  • Department of Plant Systems Biology, VIB, Department of Plant Biotechnology and Bioinformatics, Ghent University, Belgium
  • Ort: Central Building
  • Raum: Seminar Room
  • Gastgeber: Mark Stitt
Abstract: Receptor-mediated endocytosis is an integral part of signal transduction, as besides signal attenuation, by removal of activated receptors and their bound ligands from the cell surface, it allows the spatial and temporal regulation of the signaling outputs from the endosomes. After receptors have been activated and internalized, they can be separated from their ligands and recycled back to the plasma membrane or transported for degradation. Crucial in the study of the interplay between endocytosis, recycling, and signaling of plant receptor kinases is the development of imaging tools (bioactive fluorescent probes) to visualize membrane-associated signaling events at a high spatiotemporal resolution. Recently, we have been able to view endocytosis of different receptor kinases in living Arabidopsis thaliana cells using fluorescent small-molecule and peptide ligands. In addition, we are exploring the chemical biology for development of novel specific endocytosis inhibitors that will contribute to the better understanding of how this process regulates signaling outputs in plants.
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