The research within Prof. Lothar Willmitzer's department is focused on metabolism in its broadest sense, primarily using reverse genetics to alter plants and functional genomic approaches to analyse the pleiotropic effects of these alterations.
Sulfur is together with nitrogen, phosphorous and potassium a plant macronutrient and a crucial element affecting plant growth, plant performance and yield. The group of Dr. Rainer Hoefgen focuses on characterising the regulation of cysteine and methionine as a result of sulfate uptake and assimilation in the model plant Arabidopsis thaliana.
The group of Dr. Joachim Kopka, formerly known as "Root Metabolism", has a bipartite mission, on one hand the development of enabling technologies for metabolome and fluxome analysis on the other hand the application of new technology to yet unsolved problems in root physiology.
The group of Dr. Alisdair Fernie focuses on identifying factors involved in metabolic regulation of primary metabolism within both photosynthetic and heterotrophic tissues. Particular focus is given to the role of the tricarboxylic acid cycle and its participation within various biological processes.
The project group of Dr. Takayuki Tohge focuses on functional characterization of genes involved in plant secondary metabolism, especially polyphenolic pathways in Arabidopsis, tomato, tobacco, maize and rice based on translational analysis using omics studies. In particular he focuses on the elucidation of chemical diversity and regulatory roles in plant secondary metabolism in order to enable genome wide modeling of biosynthetic framework based cross-species comparison for metabolic engineering.
The scientific interest of Dr. Patrick Giavalisco's research group lies in the analysis and identification of single molecules, signaling modules or entire pathways involved in the regulation of growth- and developmental processes. For this purpose we make use of classical molecular biology and genetics approaches in combination with targeted and untargeted high resolution mass spectrometry based metabolomics and proteomics.
Research in the group of Dr. Yariv Brotman focuses on the use of quantitative genetic approaches for the identification of genes that are involved in plant metabolism, and on further functional characterization of those genes by application of different molecular biology techniques and transgenic plant approaches. Special focus is given to genes that are taking part in lipid metabolism, but also genes that are taking parts in primary and secondary metabolism are investigated. The group is also integrating knowledge from classic lipid biochemistry with lipidomics in order to refine the knowledge on lipid biochemical pathways. [more]
The research focus of the group of Dr. Zoran Nikoloski is the development of methods for integration and analysis of 'omics' (time-resolved) data from high-throughput technologies in combination with the existing biological knowledge, structured in a form of ontologies and large-scale networks, in order to glean the design principles of biological processes.
The research group of Dr. Salma Balazadeh aims to functionally characterise and identify the gene regulatory networks (GRNs) of transcription factors (TFs) involved in the adaptation of plant growth to environmental changes in the model plant Arabidopsis thaliana and transfer the knowledge obtained in Arabidopsis to crops such as tomato. The group also investigates the molecular machinery that underlies the memory and forgetfulness of stress by focusing on the role of autophagy for heat stress memory in Arabidopsis.