I have an extensive background in metabolic engineering of prokaryotic organisms. I completed my diploma thesis on polyphosphate metabolism in the institute of biotechnology at the research center Jülich. During my PhD studies, at the institute of molecular microbiology and biotechnology at Münster University, I investigated and engineered the central metabolism of C. glutamicum. I then joined the institute of Genetics of Prokaryotes at Bielefeld University, where I continued my metabolic engineering work, with a special emphasis on alternative carbon sources, sugar transport, glycolysis, and the pentose phosphate pathway. I further engineered C. glutamicum for the production of various compounds of interest. Later, I joined Algenol Biofuels in Berlin, working in strain development of Cyanobacteria. At Arren’s group I design and implement synthetic pathways for formate assimilation in E. coli, using state of the art metabolic engineering and genome editing techniques.
I gained my bachelor’s degree in biochemistry at the University of Potsdam. During my studies I became interested in microbiology, and therefore I made my Diploma thesis in intestine microbiology, studying the effect of microorganisms on the formation and excretion of potential carcinogenic nutrients. After my Diploma, I worked for a while in a medicine products company. I completed my PhD studies in the field of geological microbiology, working at the Institute of Earth and Environmental Science at the University of Potsdam. There, I developed and constructed high-pressure, high temperature incubation systems for cultivation of extremophiles as well as for the extraction of organic compounds from condensed organic matter. At AG Bar-Even, I am responsible for maintaining and operating the technical equipment, and further develop high throughput methods for measuring the equilibrium constants of enzymatic reactions under in vivo like conditions.
I received my B.Sc. degree in biology at the University of Gaziantep (Turkey), studying molecular identification of pathogens of chick-pea. I completed my master's degree at Linköping University (Sweden), where I investigated the adaptation of landrace barley to day-length and frost-conditions, making use of 19th century barley collected at different locations in Europe. I have recently obtained my PhD in Molecular Biology from the Swedish Agricultural University in Uppsala. During my PhD studies, I demonstrated a novel strategy of utilizing intermediates of the de novo fatty acid biosynthesis pathway in vegetative tissue for the production of wax esters in tobacco plants. I further introduced a new metabolic pathway to reallocate carbon flux in the endosperm of rice plant. In Dr. Bar-Even's group, I engineer synthetic photorespiration pathways, using the model bacterium E. coli as a testbed, with the aim to implement the novel routes in photosynthetic organisms.
I studied biochemistry at the University of Kent, UK, and moved into structural biology for my PhD at the EMBL in Heidelberg. After completing my PhD, I worked as a postdoc at the biochemistry department of the University of Cambridge. During my spell as a structural biologist, I studied proteins and protein complexes from a wide range of biological settings, including muscle contraction, platelet aggregation and chromatin remodelling. Having always been interested in the computational side of things, I fully switched into bioinformatics and worked at the University of Potsdam and the Max-Planck institute on predicting maize biomass yield from -omics data. In Arren Bar-Even's group, I am modelling bypass-routes for photorespiraton.
I studied for my undergraduate degree at the University of Cambridge (Part II Biochemistry), writing a short thesis on the roles of alkanes in cyanobacteria. I continued my education at Imperial College London where I studied for a Masters of Research in Structural Biology, investigating both structural mechanisms of control in the Calvin cycle and modelling residence times of water in intrinsically disordered proteins. My PhD research was also at Imperial College, where I investigated replacing the Calvin cycle in a photosynthetic bacterium, Synechocystis sp. PCC 6803, with an alternative carbon fixation cycle. In Dr. Bar-Even’s group I work to expand possible formate assimilation pathways by investigating pathways reliant on the promiscuous activities of relevant enzymes.
Being a fan of self-sufficiency, I studied Agronomy and Biotechnology at the Hebrew University (Israel) towards my bachelor's degree, imagining myself working later in the field. During that time I found out I love molecular biology and metabolism, and dedicated most of my time as a student worker learning new techniques. I did my master’s degree at the Weizmann Institute of Science (Israel) aiming, together with Arren, at metabolically engineering the bacterium E. coli to assimilate formic acid. I now continue this project at Max Planck Institute. My work revolves around the design, construction, and testing of novel metabolic routes in E. coli.
I earned my bachelor’s degree in Pharmaceutical Engineering from the National Polytechnic Institute in Mexico. I did my master’s studies at the Center for Research and Advanced Studies, also within the National Polytechnic Institute. During my master I studied genetic interactions in yeast to elucidate the mechanisms that control the ageing process. At the Max Planck Institute I metabolically engineer yeast, aiming to establish formate assimilation within this model organism.
I studied Plant Protection at the Huazhong Agricultural University in Wuhan (China) and wrote my bachelors thesis about the isolation of bioactive compounds from Atractylodes lancea. I was fascinated by the field of synthetic biology and moved to explore triterpenoids biosynthesis pathway in the edible medicinal fungi Poria cocos for my master degree, also at the Huazhong Agricultural University. In Dr. Bar-Even's group, I work on engineering E. coli to establish formaldehyde assimilation.
I studied Biochemistry at the University of Tübingen where I graduated with a thesis at the Friedrich Miescher Laboratory of the Max Planck Society on the control of robust ordering of cell cycle events. For my Master degree I moved to the University of Heidelberg and visited the University of Edinburgh. There, I worked on a variety of different projects from transcriptional regulation over optimization of photosynthesis to optogenetic tools. For my Master thesis at the Max Planck Institute for Medical Research I worked on a high-throughput protocol to test engineered light-sensitive dimers.
In Dr. Bar-Even’s Group I am investigating ways to improve photosynthesis by constructing synthetic carbon-neutral photorespiration bypass routes. Combining engineered and natural enzymes, I test novel pathways in E. coli to evaluate their functionality in vivo and perform directed evolution for further optimization.
For my undergraduate degree, I studied Molecular Biology at the University of Potsdam where I did my BSc thesis on epigenetic regulation of heat stress memory in A. thaliana. Following my interest in applied science, I moved to Strasbourg (France), where I studied Biotechnology at the École Supérieure de Biotechnologie. There, I received a double MSc degree in Synthetic Biology and Structural Biology after writing my thesis on the development of DNA Aptamers against post-transcriptionally modified proteins at the MPI for Immunology and Epigenetics in Freiburg. In the group of Dr. Bar-Even, I focus on the establishment of modified versions of the Serine-Cycle that allow formate assimilation in E.coli.
I studied Pharmaceutical Biochemistry and received a Bachelor’s degree at The National Autonomous University of Mexico, where I investigated biodiesel and biomethane production. For my Master studies, I joined the program of Biomedicine and Molecular Biotechnolgy, in the National Polytechnic Institute of Mexico. I worked in the Agricultural Microbiology group, studying the hydrolytic activities (cellulases, pectinases and xylanases) of the actinomycete Micromonospora sp. L5 for the production of second generation biofuels. As part of this project I undertook a residential research placement at the department of Microbiology and Molecular Genetics of the University of Salamanca (Spain) and a second in the School of Materials at the University of Manchester (United Kingdom). In Dr. Bar-Even’s group, I work on harnessing formate dehydrogenases and their application in plants to increase growth through formate assimilation and production.
Besides the general understanding of science, my bachelor studies in Biotechnology at the Braunschweig University of Technology gave me insights into biological cultivation processes, molecular biology and biochemistry. I did my Bachelor Thesis in the department of genetics focusing on plant-pathogen interaction. Afterwards, I decided to do my master studies in Biochemistry and Molecular Biology at the University of Potsdam. During my thesis, I followed up with engineering a part of a formate assimilation pathway designed by Dr. Arren Bar-Even. That was when my passion for metabolic engineering started and made me want to get deeper into the field. So, I started my PhD at the Max-Planck Institute working in the Group of Dr. Bar-Even exploring formatotrophic and autotrophic growth of microorganisms.
I studied Biology at the University of Bonn, gaining my B.Sc. degree investigating the biosynthesis of the gram negative cell wall and antibiotic resistance and susceptibility resulting from it in Chlamydia and E. coli. I further expanded my studies starting a M.Sc. Biochemistry and Molecular Biology at the University of Potsdam resulting in the ongoing thesis project in the group of Dr. Bar-Even, where I’m currently trying to establish a CO2 fixation process in E. coli as a starting point for consecutive formate assimilation.
I am currently studying Biology at the University of Potsdam, specializing on Molecular Biology and Physiology. During the last year, I have been working in Dr. Bar-Even’s group as a student worker and have now been given the chance to write my Bachelor Thesis in his group. In my Thesis I am focusing on establishing molecular biology methods for an alternative model organism to E. coli as well as making some basic assumptions about its metabolism. I am planning on continuing my studies at the University of Freiburg in Microbiology or Immunology.
Ever since high school I have been fascinated by the idea of engineering living power plants in order to produce desired products. During my Bachelor at the Freie Universität Berlin, I was able to gain basic theoretical and practical knowledge in all fields of biology but kept my fascination for synthetic biology. Therefore, I chose Dr. Bar-Even’s research group to complete my bachelor thesis. In my project I am rewiring Escherichia coli’s central metabolism in order to establish a novel fermentation pathway with promising biotechnical properties. Starting in February 2018, I am going to continue my studies at the ETH in Zürich where I am doing a Master in Biology with a Major in biochemistry.
I am currently studying Chemical and Biotechnical Science in Denmark for AP degree and I am planning to continue for my PhD. I am big fan of science in general and my current projects and studies are giving me chance to be in touch with science. In my projects, I am studying pyruvate formate lyase dependent growth of E.coli under various conditions. In future I would like to either stay focused on studying molecular biology or study molecular biophysics or bioinformatics.